Chirality and structure-selective MALDI using mold matrix

Hydrazinonicotinic acid as a novel matrix for highly sensitive and selective MALDI-MS analysis of oligosaccharides.

Analysis of oligosaccharides with matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) remains challenging due to their low ionization efficiency. The sensitivity achieved by MS for oligosaccharides lags far behind that for proteins/peptides. Here, hydrazinonicotinic acid (HYNIC) is proposed as a new matrix to realize highly sensitive and selective analysis of oligosaccharid...

Selective detection of alkaloids in MALDI-TOF: the introduction of a novel matrix molecule.

The current manuscript presents 3-[5'-(methylthio)-2,2'-bithiophen-5-ylthio]propanenitrile (MT3P), as a novel matrix molecule, which facilitates the selective ionization of alkaloids in matrix-assisted laser desorption/ionization mass spectrometry. Exhibiting strong ionizing properties at low levels of laser energy, MT3P was evaluated on 55 compounds belonging to various chemical families. The ...

Matrix-Assisted Laser Desorption/Ionization (MALDI)

Phase chirality and stereo-selective swelling of cholesteric elastomers.

Cholesteric elastomers possess a macroscopic "phase chirality" as the director n rotates in a helical fashion along an optical axis z and can be described by a chiral order parameter alpha. This parameter can be tuned by changing the helix pitch p and the elastic properties of the network at formation. The cholesterics also possess a local nematic order, changing with temperature or during solv...

Exciton mobility and trapping in a MALDI matrix.

Energy transfer (ET) from excited matrix to fluorescent traps is used to probe the mobility of excitations in the matrix-assisted laser desorption/ionization (MALDI) matrix material 2,5-dihydroxybenzoic acid. The dependence of host and guest fluorescence on excitation density (laser intensity) and trap concentration gives clear evidence for long-range energy transport in this matrix. This concl...